LQT genotype–phenotype relationships: patients and patches
نویسندگان
چکیده
منابع مشابه
An LQT mutant minK alters KvLQT1 trafficking.
Cardiac I(Ks), the slowly activated delayed-rectifier K(+) current, is produced by the protein complex composed of alpha- and beta-subunits: KvLQT1 and minK. Mutations of genes encoding KvLQT1 and minK are responsible for the hereditary long QT syndrome (loci LQT1 and LQT5, respectively). MinK-L51H fails to traffic to the cell surface, thereby failing to produce effective I(Ks). We examined the...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2001
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(01)00389-3